Cargando…

Inhibition of miR-25 Improves Cardiac Contractility in the Failing Heart

Heart failure is characterized by a debilitating decline in cardiac function(1), and recent clinical trial results indicate that improving the contractility of heart muscle cells by boosting intracellular calcium handling might be an effective therapy(2,3). microRNAs (miRs) are dysregulated with hea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wahlquist, Christine, Jeong, Dongtak, Rojas-Muñoz, Agustin, Kho, Changwon, Lee, Ahyoung, Mitsuyama, Shinichi, van Mil, Alain, Jin Park, Woo, Sluijter, Joost P. G., Doevendans, Pieter A. F., Hajjar, Roger J., Mercola, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131725/ https://www.ncbi.nlm.nih.gov/pubmed/24670661 http://dx.doi.org/10.1038/nature13073

Ejemplares similares

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a
por: Lei, Zhiyong, et al.
Publicado: (2021)

SUMO1-dependent modulation of SERCA2a in heart failure
por: Kho, Changwon, et al.
Publicado: (2011)

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
por: Kho, Changwon, et al.
Publicado: (2015)

Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a
por: Gorski, Przemek A., et al.
Publicado: (2023)

Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart Diseases
por: Hwang, Jin-Taek, et al.
Publicado: (2022)

MicroRNAs in Dystrophinopathy
por: Lee, Ahyoung, et al.
Publicado: (2022)

MMISH: Multicolor microRNA in situ hybridization for paraffin embedded samples
por: Lei, Zhiyong, et al.
Publicado: (2018)

Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes
por: Peters, Marijn C, et al.
Publicado: (2022)

MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1
por: Liu, Jia, et al.
Publicado: (2011)

Analysis of extracellular vesicle miRNA profiles in heart failure
por: Oh, Jae Gyun, et al.
Publicado: (2020)

Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step
por: Kristen, Marleen, et al.
Publicado: (2020)

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel
por: van der Ven, Casper F. T., et al.
Publicado: (2021)

Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts
por: Peters, Marijn C., et al.
Publicado: (2022)

MicroRNA-132/212 family enhances arteriogenesis after hindlimb ischaemia through modulation of the Ras-MAPK pathway
por: Lei, Zhiyong, et al.
Publicado: (2015)

Human cardiomyocyte progenitor cells: a short history of nearly everything
por: Vliet, Patrick, et al.
Publicado: (2012)

MiR-155 inhibits cell migration of human cardiomyocyte progenitor cells (hCMPCs) via targeting of MMP-16
por: Liu, Jia, et al.
Publicado: (2012)

Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs
por: Oerlemans, Martinus I F J, et al.
Publicado: (2012)

CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response
por: Ceholski, Delaine K., et al.
Publicado: (2017)

Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study
por: Kirn, Borut, et al.
Publicado: (2018)

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium
por: Wijnker, Paul J. M., et al.
Publicado: (2011)

Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart
por: Lehnart, Stephan E., et al.
Publicado: (2009)

Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts
por: McDonald, Kerry S., et al.
Publicado: (2020)

Enhancing atrial‐specific gene expression using a calsequestrin cis‐regulatory module 4 with a sarcolipin promoter
por: Yoo, Jimeen, et al.
Publicado: (2018)

Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes
por: Chirico, Nino, et al.
Publicado: (2022)

Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR‐181a in a Rodent Chronic Myocardial Infarction Model
por: Vaskova, Evgeniya, et al.
Publicado: (2020)

Effect of hypothyroidism on contractile performance of isolated end-stage failing human myocardium
por: Saad, Nancy S., et al.
Publicado: (2022)

Targeting calcium regulators as therapy for heart failure: focus on the sarcoplasmic reticulum Ca-ATPase pump
por: Kho, Changwon
Publicado: (2023)

Active Wnt signaling in response to cardiac injury
por: Oerlemans, Martinus I. F. J., et al.
Publicado: (2010)

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression
por: Lee, Cholong, et al.
Publicado: (2023)

Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals
por: de Wit, Lousanne, et al.
Publicado: (2020)

Highly variable contractile performance correlates with myocyte content in trabeculae from failing human hearts
por: Munro, Michelle L., et al.
Publicado: (2018)

Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
por: Calamera, Gaia, et al.
Publicado: (2022)

Targeting chronic cardiac remodeling with cardiac progenitor cells in a murine model of ischemia/reperfusion injury
por: Deddens, Janine C., et al.
Publicado: (2017)

MicroRNAs and Calcium Signaling in Heart Disease
por: Park, Jae-Ho, et al.
Publicado: (2021)

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality
por: el Azzouzi, Hamid, et al.
Publicado: (2020)

Therapeutic Cardiac‐Targeted Delivery of miR‐1 Reverses Pressure Overload–Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling
por: Karakikes, Ioannis, et al.
Publicado: (2013)

Atrial stretch and arrhythmia after myocardial infarction
por: Bikou, Olympia, et al.
Publicado: (2018)

Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity
por: Gaetani, Roberto, et al.
Publicado: (2014)

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice
por: Lei, Zhiyong, et al.
Publicado: (2020)

Control of Angiogenesis via a VHL/miR-212/132 Axis
por: Lei, Zhiyong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gukjhomgpnqt12s4f3kiuunkmd