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Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program

A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles, mumps and rubella (MMR) immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009, without other vaccines administered during the...

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Autores principales: dos Santos, Eliane Matos, Sá, Gloria Regina da Silva e, Siqueira, Marilda Mendonça, Martins, Reinaldo de Menezes, Camacho, Luiz Antonio Bastos, von Doellinger, Vanessa dos Reis, Maia, Maria de Lourdes de Sousa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131786/
https://www.ncbi.nlm.nih.gov/pubmed/24821058
http://dx.doi.org/10.1590/0074-0276130351
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author dos Santos, Eliane Matos
Sá, Gloria Regina da Silva e
Siqueira, Marilda Mendonça
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
von Doellinger, Vanessa dos Reis
Maia, Maria de Lourdes de Sousa
author_facet dos Santos, Eliane Matos
Sá, Gloria Regina da Silva e
Siqueira, Marilda Mendonça
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
von Doellinger, Vanessa dos Reis
Maia, Maria de Lourdes de Sousa
author_sort dos Santos, Eliane Matos
collection PubMed
description A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles, mumps and rubella (MMR) immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009, without other vaccines administered during the period from 30 days before to 30 days after vaccination. A previous study conducted in Brazil in 2007, in 1,769 children ranging from 12-15 months of age vaccinated against yellow fever and MMR simultaneously or at intervals of 30 days or more between doses, had shown low seroconversion for mumps regardless of the interval between administration of the two vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0) seroconversion rate for mumps. All children seroconverted for measles and rubella. After revaccination, high antibody titres and seroconversion rates were achieved against mumps. The results of this study and others suggest that two MMR doses confer optimal immunoresponses for all three antigens and the possible need for additional doses should be studied taking into account not only serological, but also epidemiological data, as there is no serological correlate of protection for mumps.
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spelling pubmed-41317862014-08-14 Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program dos Santos, Eliane Matos Sá, Gloria Regina da Silva e Siqueira, Marilda Mendonça Martins, Reinaldo de Menezes Camacho, Luiz Antonio Bastos von Doellinger, Vanessa dos Reis Maia, Maria de Lourdes de Sousa Mem Inst Oswaldo Cruz Articles A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles, mumps and rubella (MMR) immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009, without other vaccines administered during the period from 30 days before to 30 days after vaccination. A previous study conducted in Brazil in 2007, in 1,769 children ranging from 12-15 months of age vaccinated against yellow fever and MMR simultaneously or at intervals of 30 days or more between doses, had shown low seroconversion for mumps regardless of the interval between administration of the two vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0) seroconversion rate for mumps. All children seroconverted for measles and rubella. After revaccination, high antibody titres and seroconversion rates were achieved against mumps. The results of this study and others suggest that two MMR doses confer optimal immunoresponses for all three antigens and the possible need for additional doses should be studied taking into account not only serological, but also epidemiological data, as there is no serological correlate of protection for mumps. Instituto Oswaldo Cruz, Ministério da Saúde 2014-05-07 2014-06 /pmc/articles/PMC4131786/ /pubmed/24821058 http://dx.doi.org/10.1590/0074-0276130351 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
dos Santos, Eliane Matos
Sá, Gloria Regina da Silva e
Siqueira, Marilda Mendonça
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
von Doellinger, Vanessa dos Reis
Maia, Maria de Lourdes de Sousa
Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
title Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
title_full Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
title_fullStr Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
title_full_unstemmed Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
title_short Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
title_sort immune response to the mumps component of the mmr vaccine in the routine of immunisation services in the brazilian national immunisation program
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131786/
https://www.ncbi.nlm.nih.gov/pubmed/24821058
http://dx.doi.org/10.1590/0074-0276130351
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