The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms

Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both prolif...

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Autores principales: Sales, Policarpo Ademar, Rezende, Celso Oliveira, Le Hyaric, Mireille, de Almeida, Mauro Vieira, Romanha, Alvaro José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131791/
https://www.ncbi.nlm.nih.gov/pubmed/24831550
http://dx.doi.org/10.1590/0074-0276130496
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author Sales, Policarpo Ademar
Rezende, Celso Oliveira
Le Hyaric, Mireille
de Almeida, Mauro Vieira
Romanha, Alvaro José
author_facet Sales, Policarpo Ademar
Rezende, Celso Oliveira
Le Hyaric, Mireille
de Almeida, Mauro Vieira
Romanha, Alvaro José
author_sort Sales, Policarpo Ademar
collection PubMed
description Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
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spelling pubmed-41317912014-08-14 The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms Sales, Policarpo Ademar Rezende, Celso Oliveira Le Hyaric, Mireille de Almeida, Mauro Vieira Romanha, Alvaro José Mem Inst Oswaldo Cruz Articles Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4). Instituto Oswaldo Cruz, Ministério da Saúde 2014-04-25 2014-06 /pmc/articles/PMC4131791/ /pubmed/24831550 http://dx.doi.org/10.1590/0074-0276130496 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Sales, Policarpo Ademar
Rezende, Celso Oliveira
Le Hyaric, Mireille
de Almeida, Mauro Vieira
Romanha, Alvaro José
The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
title The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
title_full The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
title_fullStr The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
title_full_unstemmed The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
title_short The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
title_sort in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote trypanosoma cruzi forms
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131791/
https://www.ncbi.nlm.nih.gov/pubmed/24831550
http://dx.doi.org/10.1590/0074-0276130496
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