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Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System

Chronic monitoring of heart rate, blood pressure, and flow in conscious free-roaming large animals can offer considerable opportunity to understand the progression of cardiovascular diseases and can test new diagnostics and therapeutics. The objective of this study was to demonstrate the feasibility...

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Autores principales: Choy, Jenny S., Zhang, Zhen-Du, Pitsillides, Koullis, Sosa, Margo, Kassab, Ghassan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131878/
https://www.ncbi.nlm.nih.gov/pubmed/25119289
http://dx.doi.org/10.1371/journal.pone.0103331
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author Choy, Jenny S.
Zhang, Zhen-Du
Pitsillides, Koullis
Sosa, Margo
Kassab, Ghassan S.
author_facet Choy, Jenny S.
Zhang, Zhen-Du
Pitsillides, Koullis
Sosa, Margo
Kassab, Ghassan S.
author_sort Choy, Jenny S.
collection PubMed
description Chronic monitoring of heart rate, blood pressure, and flow in conscious free-roaming large animals can offer considerable opportunity to understand the progression of cardiovascular diseases and can test new diagnostics and therapeutics. The objective of this study was to demonstrate the feasibility of chronic, simultaneous measurement of several hemodynamic parameters (left ventricular pressure, systemic pressure, blood flow velocity, and heart rate) using a totally implantable multichannel telemetry system in swine heart failure models. Two solid-state blood pressure sensors were inserted in the left ventricle and the descending aorta for pressure measurements. Two Doppler probes were placed around the left anterior descending (LAD) and the brachiocephalic arteries for blood flow velocity measurements. Electrocardiographic (ECG) electrodes were attached to the surface of the left ventricle to monitor heart rate. The telemeter body was implanted in the right side of the abdomen under the skin for approximately 4 to 6 weeks. The animals were subjected to various heart failure models, including volume overload (A-V fistula, n = 3), pressure overload (aortic banding, n = 2) and dilated cardiomyopathy (pacing-induced tachycardia, n = 3). Longitudinal changes in hemodynamics were monitored during the progression of the disease. In the pacing-induced tachycardia animals, the systemic blood pressure progressively decreased within the first 2 weeks and returned to baseline levels thereafter. In the aortic banding animals, the pressure progressively increased during the development of the disease. The pressure in the A-V fistula animals only showed a small increase during the first week and remained stable thereafter. The results demonstrated the ability of this telemetry system of long-term, simultaneous monitoring of blood flow, pressure and heart rate in heart failure models, which may offer significant utility for understanding cardiovascular disease progression and treatment.
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spelling pubmed-41318782014-08-19 Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System Choy, Jenny S. Zhang, Zhen-Du Pitsillides, Koullis Sosa, Margo Kassab, Ghassan S. PLoS One Research Article Chronic monitoring of heart rate, blood pressure, and flow in conscious free-roaming large animals can offer considerable opportunity to understand the progression of cardiovascular diseases and can test new diagnostics and therapeutics. The objective of this study was to demonstrate the feasibility of chronic, simultaneous measurement of several hemodynamic parameters (left ventricular pressure, systemic pressure, blood flow velocity, and heart rate) using a totally implantable multichannel telemetry system in swine heart failure models. Two solid-state blood pressure sensors were inserted in the left ventricle and the descending aorta for pressure measurements. Two Doppler probes were placed around the left anterior descending (LAD) and the brachiocephalic arteries for blood flow velocity measurements. Electrocardiographic (ECG) electrodes were attached to the surface of the left ventricle to monitor heart rate. The telemeter body was implanted in the right side of the abdomen under the skin for approximately 4 to 6 weeks. The animals were subjected to various heart failure models, including volume overload (A-V fistula, n = 3), pressure overload (aortic banding, n = 2) and dilated cardiomyopathy (pacing-induced tachycardia, n = 3). Longitudinal changes in hemodynamics were monitored during the progression of the disease. In the pacing-induced tachycardia animals, the systemic blood pressure progressively decreased within the first 2 weeks and returned to baseline levels thereafter. In the aortic banding animals, the pressure progressively increased during the development of the disease. The pressure in the A-V fistula animals only showed a small increase during the first week and remained stable thereafter. The results demonstrated the ability of this telemetry system of long-term, simultaneous monitoring of blood flow, pressure and heart rate in heart failure models, which may offer significant utility for understanding cardiovascular disease progression and treatment. Public Library of Science 2014-08-13 /pmc/articles/PMC4131878/ /pubmed/25119289 http://dx.doi.org/10.1371/journal.pone.0103331 Text en © 2014 Choy et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Choy, Jenny S.
Zhang, Zhen-Du
Pitsillides, Koullis
Sosa, Margo
Kassab, Ghassan S.
Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System
title Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System
title_full Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System
title_fullStr Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System
title_full_unstemmed Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System
title_short Longitudinal Hemodynamic Measurements in Swine Heart Failure Using a Fully Implantable Telemetry System
title_sort longitudinal hemodynamic measurements in swine heart failure using a fully implantable telemetry system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131878/
https://www.ncbi.nlm.nih.gov/pubmed/25119289
http://dx.doi.org/10.1371/journal.pone.0103331
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