Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate–Histidine Hydrogen Bond

[Image: see text] The structural basis of the regulation of microsomal cytochrome P450 (P450) activity was investigated by mutating the highly conserved heme binding motif residue, Phe429, on the proximal side of cytochrome P450 2B4 to a histidine. Spectroscopic, pre-steady-state and steady-state ki...

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Detalles Bibliográficos
Autores principales: Yang, Yuting, Zhang, Haoming, Usharani, Dandamudi, Bu, Weishu, Im, Sangchoul, Tarasev, Michael, Rwere, Freeborn, Pearl, Naw May, Meagher, Jennifer, Sun, Cuthbert, Stuckey, Jeanne, Shaik, Sason, Waskell, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131899/
https://www.ncbi.nlm.nih.gov/pubmed/25029089
http://dx.doi.org/10.1021/bi5003794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131899/
https://www.ncbi.nlm.nih.gov/pubmed/25029089
http://dx.doi.org/10.1021/bi5003794

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