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Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases

INTRODUCTION: Keratoacanthoma (KA) and invasive squamous cell carcinoma (SCC) are keratinocytic tumors displaying vascular features, imaged using dermatoscopy. OBJECTIVE: Compare the dermatoscopy vascular features of KA to SCC. METHODS: This prospective study examined consecutive cases of 100 KA and...

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Autores principales: Pyne, John H., Windrum, Graham, Sapkota, Devendra, Wong, Jian Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Derm101.com 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131996/
https://www.ncbi.nlm.nih.gov/pubmed/25126456
http://dx.doi.org/10.5826/dpc.0403a06
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author Pyne, John H.
Windrum, Graham
Sapkota, Devendra
Wong, Jian Cheng
author_facet Pyne, John H.
Windrum, Graham
Sapkota, Devendra
Wong, Jian Cheng
author_sort Pyne, John H.
collection PubMed
description INTRODUCTION: Keratoacanthoma (KA) and invasive squamous cell carcinoma (SCC) are keratinocytic tumors displaying vascular features, imaged using dermatoscopy. OBJECTIVE: Compare the dermatoscopy vascular features of KA to SCC. METHODS: This prospective study examined consecutive cases of 100 KA and 410 invasive SCC in a single private practice in Sydney, Australia. Vascular features were recorded in vivo direct from patients using a non-polarized Delta 20 Heine dermatoscope. These vascular features were: linear, branching, serpentine, hairpin, glomerular and dot vessels, the presence or absence of large diameter tumor vessels, vessel presence in central verses peripheral tumor areas and tumor pink areas in different proportions. Following full excision, all cases were submitted for histopathologic diagnosis. RESULTS: Branching vessels were the only vessel morphology that varied, with a significant incidence in KA (25.0%), compared to SCC (10.7%), P < 0.01. Large vessels were identified in 20.0% of KA, compared to 12.4% in SCC, P = 0.05. No vessels were observed in the central tumor areas in 43.4 % of KA compared to 58.0% of SCC, P = 0.01. Other data comparing the central versus peripheral tumor areas for vessels present did not reveal any distinctive associations. There were no significant differences between KA and SCC when reviewing the selected proportions of pink within the tumor. LIMITATIONS: The vascular features may be confounded by tumor depth in KA. Polarized dermatoscopy may not produce the same findings. CONCLUSION: This study found branching vessels to have a higher incidence in KA compared to invasive SCC. Although not statistically significant, large diameter vessels were also more frequent in KA. Proportions of pink within the tumor or central verses peripheral tumor vessel distribution were not useful diagnostic features separating KA from SCC using dermatoscopy.
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spelling pubmed-41319962014-08-14 Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases Pyne, John H. Windrum, Graham Sapkota, Devendra Wong, Jian Cheng Dermatol Pract Concept Research INTRODUCTION: Keratoacanthoma (KA) and invasive squamous cell carcinoma (SCC) are keratinocytic tumors displaying vascular features, imaged using dermatoscopy. OBJECTIVE: Compare the dermatoscopy vascular features of KA to SCC. METHODS: This prospective study examined consecutive cases of 100 KA and 410 invasive SCC in a single private practice in Sydney, Australia. Vascular features were recorded in vivo direct from patients using a non-polarized Delta 20 Heine dermatoscope. These vascular features were: linear, branching, serpentine, hairpin, glomerular and dot vessels, the presence or absence of large diameter tumor vessels, vessel presence in central verses peripheral tumor areas and tumor pink areas in different proportions. Following full excision, all cases were submitted for histopathologic diagnosis. RESULTS: Branching vessels were the only vessel morphology that varied, with a significant incidence in KA (25.0%), compared to SCC (10.7%), P < 0.01. Large vessels were identified in 20.0% of KA, compared to 12.4% in SCC, P = 0.05. No vessels were observed in the central tumor areas in 43.4 % of KA compared to 58.0% of SCC, P = 0.01. Other data comparing the central versus peripheral tumor areas for vessels present did not reveal any distinctive associations. There were no significant differences between KA and SCC when reviewing the selected proportions of pink within the tumor. LIMITATIONS: The vascular features may be confounded by tumor depth in KA. Polarized dermatoscopy may not produce the same findings. CONCLUSION: This study found branching vessels to have a higher incidence in KA compared to invasive SCC. Although not statistically significant, large diameter vessels were also more frequent in KA. Proportions of pink within the tumor or central verses peripheral tumor vessel distribution were not useful diagnostic features separating KA from SCC using dermatoscopy. Derm101.com 2014-07-31 /pmc/articles/PMC4131996/ /pubmed/25126456 http://dx.doi.org/10.5826/dpc.0403a06 Text en Copyright: ©2014 Pyne et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research
Pyne, John H.
Windrum, Graham
Sapkota, Devendra
Wong, Jian Cheng
Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
title Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
title_full Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
title_fullStr Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
title_full_unstemmed Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
title_short Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
title_sort keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131996/
https://www.ncbi.nlm.nih.gov/pubmed/25126456
http://dx.doi.org/10.5826/dpc.0403a06
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