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Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13
BACKGROUND: Bone metastasis (BM) is a frequent complication in patients with advanced lung cancer and it causes skeletal-related events (SREs). Our study aim is to prospectively investigate the incidence of BM, incidence and types of SRE, and predictive factors of BM and SREs. METHODS: Newly diagnos...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132043/ https://www.ncbi.nlm.nih.gov/pubmed/24419421 http://dx.doi.org/10.1097/JTO.0000000000000051 |
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author | Katakami, Nobuyuki Kunikane, Hiroshi Takeda, Koji Takayama, Koichi Sawa, Toshiyuki Saito, Hiroshi Harada, Masao Yokota, Soichiro Ando, Kiyoshi Saito, Yuko Yokota, Isao Ohashi, Yasuo Eguchi, Kenji |
author_facet | Katakami, Nobuyuki Kunikane, Hiroshi Takeda, Koji Takayama, Koichi Sawa, Toshiyuki Saito, Hiroshi Harada, Masao Yokota, Soichiro Ando, Kiyoshi Saito, Yuko Yokota, Isao Ohashi, Yasuo Eguchi, Kenji |
author_sort | Katakami, Nobuyuki |
collection | PubMed |
description | BACKGROUND: Bone metastasis (BM) is a frequent complication in patients with advanced lung cancer and it causes skeletal-related events (SREs). Our study aim is to prospectively investigate the incidence of BM, incidence and types of SRE, and predictive factors of BM and SREs. METHODS: Newly diagnosed, advanced non–small-cell lung cancer (NSCLC) or small-cell lung cancer (SCLC) patients were enrolled into the study. Patients were followed up every 4 weeks to monitor the development of SREs. Treatment for lung cancer was performed at the discretion of the investigator. RESULTS: Two hundred seventy-four patients were enrolled in this study between April 2007 and December 2009 from 12 institutions. Patients included 77 cases of SCLC and 197 of NSCLC (stage IIIB/IV = 73/124). Median follow-up time was 13.8 months. The incidence of BM at initial diagnosis was 48% in stage IV NSCLC and 40% in extensive stage (ED)-SCLC. Forty-five percent of patients who developed BM had SREs consisting of pathologic fracture (4.7%), radiation to bone (15.3%), spinal cord compression (1.1%), and hypercalcemia (2.2%). Multivariate analysis revealed that factors predicting BM are stage IV, performance status 1 or greater and higher bone alkaline phosphatase in NSCLC patients, higher lactate dehydrogenase, and lower parathyroid hormone–related peptide in SCLC patients. Factors predicting SREs were stage IV, age 64 or younger, and lower albumin in NSCLC patients. Multivariate analysis of SRE was not performed for SCLC because of the small number of events. CONCLUSION: Predictive factors should be taken into consideration in future randomized studies evaluating BM and SREs. |
format | Online Article Text |
id | pubmed-4132043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-41320432014-08-14 Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 Katakami, Nobuyuki Kunikane, Hiroshi Takeda, Koji Takayama, Koichi Sawa, Toshiyuki Saito, Hiroshi Harada, Masao Yokota, Soichiro Ando, Kiyoshi Saito, Yuko Yokota, Isao Ohashi, Yasuo Eguchi, Kenji J Thorac Oncol Original Articles BACKGROUND: Bone metastasis (BM) is a frequent complication in patients with advanced lung cancer and it causes skeletal-related events (SREs). Our study aim is to prospectively investigate the incidence of BM, incidence and types of SRE, and predictive factors of BM and SREs. METHODS: Newly diagnosed, advanced non–small-cell lung cancer (NSCLC) or small-cell lung cancer (SCLC) patients were enrolled into the study. Patients were followed up every 4 weeks to monitor the development of SREs. Treatment for lung cancer was performed at the discretion of the investigator. RESULTS: Two hundred seventy-four patients were enrolled in this study between April 2007 and December 2009 from 12 institutions. Patients included 77 cases of SCLC and 197 of NSCLC (stage IIIB/IV = 73/124). Median follow-up time was 13.8 months. The incidence of BM at initial diagnosis was 48% in stage IV NSCLC and 40% in extensive stage (ED)-SCLC. Forty-five percent of patients who developed BM had SREs consisting of pathologic fracture (4.7%), radiation to bone (15.3%), spinal cord compression (1.1%), and hypercalcemia (2.2%). Multivariate analysis revealed that factors predicting BM are stage IV, performance status 1 or greater and higher bone alkaline phosphatase in NSCLC patients, higher lactate dehydrogenase, and lower parathyroid hormone–related peptide in SCLC patients. Factors predicting SREs were stage IV, age 64 or younger, and lower albumin in NSCLC patients. Multivariate analysis of SRE was not performed for SCLC because of the small number of events. CONCLUSION: Predictive factors should be taken into consideration in future randomized studies evaluating BM and SREs. Lippincott Williams & Wilkins 2014-02 2014-01-23 /pmc/articles/PMC4132043/ /pubmed/24419421 http://dx.doi.org/10.1097/JTO.0000000000000051 Text en Copyright © 2013 by the International Association for the Study of Lung Cancer This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Original Articles Katakami, Nobuyuki Kunikane, Hiroshi Takeda, Koji Takayama, Koichi Sawa, Toshiyuki Saito, Hiroshi Harada, Masao Yokota, Soichiro Ando, Kiyoshi Saito, Yuko Yokota, Isao Ohashi, Yasuo Eguchi, Kenji Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 |
title | Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 |
title_full | Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 |
title_fullStr | Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 |
title_full_unstemmed | Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 |
title_short | Prospective Study on the Incidence of Bone Metastasis (BM) and Skeletal-Related Events (SREs) in Patients (pts) with Stage IIIB and IV Lung Cancer—CSP-HOR 13 |
title_sort | prospective study on the incidence of bone metastasis (bm) and skeletal-related events (sres) in patients (pts) with stage iiib and iv lung cancer—csp-hor 13 |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132043/ https://www.ncbi.nlm.nih.gov/pubmed/24419421 http://dx.doi.org/10.1097/JTO.0000000000000051 |
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