The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small mol...

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Detalles Bibliográficos
Autores principales: Chuang, Hui-Ching, Yang, Liang Peng, Fitzgerald, Alison L., Osman, Abdullah, Woo, Sang Hyeok, Myers, Jeffrey N., Skinner, Heath D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132078/
https://www.ncbi.nlm.nih.gov/pubmed/25119136
http://dx.doi.org/10.1371/journal.pone.0104821

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