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Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study

BACKGROUND: We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD) from the Clinical Research Center for Dementia of South Korea (CREDOS)-FTD registry. METHODS: A total of 200 consecutive patients with FTD recruited from 16 neurological cli...

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Autores principales: Kim, Eun-Joo, Park, Kyung-Won, Lee, Jae-Hong, Choi, SeongHye, Jeong, Jee H., Yoon, Soo Jin, Kim, Byeong C., Kwon, Jay C., Ku, Bon D., Kim, Seung Hyun, Choi, Byung-Ok, Na, Duk L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132251/
https://www.ncbi.nlm.nih.gov/pubmed/25177333
http://dx.doi.org/10.1159/000360278
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author Kim, Eun-Joo
Park, Kyung-Won
Lee, Jae-Hong
Choi, SeongHye
Jeong, Jee H.
Yoon, Soo Jin
Kim, Byeong C.
Kwon, Jay C.
Ku, Bon D.
Kim, Seung Hyun
Choi, Byung-Ok
Na, Duk L.
author_facet Kim, Eun-Joo
Park, Kyung-Won
Lee, Jae-Hong
Choi, SeongHye
Jeong, Jee H.
Yoon, Soo Jin
Kim, Byeong C.
Kwon, Jay C.
Ku, Bon D.
Kim, Seung Hyun
Choi, Byung-Ok
Na, Duk L.
author_sort Kim, Eun-Joo
collection PubMed
description BACKGROUND: We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD) from the Clinical Research Center for Dementia of South Korea (CREDOS)-FTD registry. METHODS: A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive and functional assessments, a screening test for aphasia, behavioral questionnaires, motor assessments, and brain MRI or PET. RESULTS: In our registry, 78 patients were classified as having been diagnosed with behavioral-variant FTD (bvFTD), 70 with semantic dementia (SD), 33 with progressive nonfluent aphasia (PNFA), and 8 with motor neuron disease plus syndrome (MND-plus). The patients with language variants of dementia were older than those with bvFTD. There were no differences in sex ratio, duration of illness, or level of education among the four subgroups. Overall, the patients with bvFTD showed a significantly better performance in cognitive tests. A higher frequency of motor symptoms and a lower frequency of behavioral symptoms were found in PNFA than in bvFTD and SD. The Global Language Index was significantly lower in SD than in bvFTD and PNFA. The MND-plus group had a poorer performance than all the others in all cognitive domains. CONCLUSION: The neuropsychological, behavioral, motor, and language characteristics of the four subtypes are comparable with those from other series. However, the proportion of SD (37.0%), which was similar to that of bvFTD (41.3%), was higher in our registry than in other series.
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spelling pubmed-41322512014-08-29 Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study Kim, Eun-Joo Park, Kyung-Won Lee, Jae-Hong Choi, SeongHye Jeong, Jee H. Yoon, Soo Jin Kim, Byeong C. Kwon, Jay C. Ku, Bon D. Kim, Seung Hyun Choi, Byung-Ok Na, Duk L. Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND: We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD) from the Clinical Research Center for Dementia of South Korea (CREDOS)-FTD registry. METHODS: A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive and functional assessments, a screening test for aphasia, behavioral questionnaires, motor assessments, and brain MRI or PET. RESULTS: In our registry, 78 patients were classified as having been diagnosed with behavioral-variant FTD (bvFTD), 70 with semantic dementia (SD), 33 with progressive nonfluent aphasia (PNFA), and 8 with motor neuron disease plus syndrome (MND-plus). The patients with language variants of dementia were older than those with bvFTD. There were no differences in sex ratio, duration of illness, or level of education among the four subgroups. Overall, the patients with bvFTD showed a significantly better performance in cognitive tests. A higher frequency of motor symptoms and a lower frequency of behavioral symptoms were found in PNFA than in bvFTD and SD. The Global Language Index was significantly lower in SD than in bvFTD and PNFA. The MND-plus group had a poorer performance than all the others in all cognitive domains. CONCLUSION: The neuropsychological, behavioral, motor, and language characteristics of the four subtypes are comparable with those from other series. However, the proportion of SD (37.0%), which was similar to that of bvFTD (41.3%), was higher in our registry than in other series. S. Karger AG 2014-07-10 /pmc/articles/PMC4132251/ /pubmed/25177333 http://dx.doi.org/10.1159/000360278 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Research Article
Kim, Eun-Joo
Park, Kyung-Won
Lee, Jae-Hong
Choi, SeongHye
Jeong, Jee H.
Yoon, Soo Jin
Kim, Byeong C.
Kwon, Jay C.
Ku, Bon D.
Kim, Seung Hyun
Choi, Byung-Ok
Na, Duk L.
Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
title Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
title_full Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
title_fullStr Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
title_full_unstemmed Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
title_short Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
title_sort clinical and neuropsychological characteristics of a nationwide hospital-based registry of frontotemporal dementia patients in korea: a credos-ftd study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132251/
https://www.ncbi.nlm.nih.gov/pubmed/25177333
http://dx.doi.org/10.1159/000360278
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