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Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

BACKGROUND: Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central event in the pathogenesis of Alzheimer’s disease (AD). Besides the parenchymal pathology, Aβ is known to undergo active transport across the blood–brain barrier and cerebral amyloid angiopathy (CAA) is a pro...

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Detalles Bibliográficos
Autores principales:	Li, Hongmei, Guo, Qinxi, Inoue, Taeko, Polito, Vinicia A, Tabuchi, Katsuhiko, Hammer, Robert E, Pautler, Robia G, Taffet, George E, Zheng, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132280/ https://www.ncbi.nlm.nih.gov/pubmed/25108425 http://dx.doi.org/10.1186/1750-1326-9-28

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