ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

Amyotrophic Lateral Sclerosis (ALS) is being redefined as a distal axonopathy, in that many molecular changes influencing motor neuron degeneration occur at the neuromuscular junction (NMJ) at very early stages of the disease prior to symptom onset. A huge variety of genetic and environmental causes...

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Detalles Bibliográficos
Autores principales: Moloney, Elizabeth B., de Winter, Fred, Verhaagen, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132373/
https://www.ncbi.nlm.nih.gov/pubmed/25177267
http://dx.doi.org/10.3389/fnins.2014.00252

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