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Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis

Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth. Clinical studies rep...

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Autores principales: Locatelli, Vittorio, Bianchi, Vittorio E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132406/
https://www.ncbi.nlm.nih.gov/pubmed/25147565
http://dx.doi.org/10.1155/2014/235060
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author Locatelli, Vittorio
Bianchi, Vittorio E.
author_facet Locatelli, Vittorio
Bianchi, Vittorio E.
author_sort Locatelli, Vittorio
collection PubMed
description Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth. Clinical studies reporting the use of GH and IGF-1 in osteoporosis and fracture healing are outlined. Methods. A Pubmed search revealed 39 clinical studies reporting the effects of GH and IGF-1 administration on bone metabolism in osteopenic and osteoporotic human subjects and on bone healing in operated patients with normal GH secretion. Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administration, and seven related to the GH/IGF-1 effect on bone healing. Results. Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies. GH/IGF-1 administration in patients with hip or tibial fractures resulted in increased bone healing, rapid clinical improvements. Some conflicting results were evidenced. Conclusions. GH and IGF-1 therapy has a significant anabolic effect. GH administration for the treatment of osteoporosis and bone fractures may greatly improve clinical outcome. GH interacts with sex steroids in the anabolic process. GH resistance process is considered.
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spelling pubmed-41324062014-08-21 Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis Locatelli, Vittorio Bianchi, Vittorio E. Int J Endocrinol Review Article Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth. Clinical studies reporting the use of GH and IGF-1 in osteoporosis and fracture healing are outlined. Methods. A Pubmed search revealed 39 clinical studies reporting the effects of GH and IGF-1 administration on bone metabolism in osteopenic and osteoporotic human subjects and on bone healing in operated patients with normal GH secretion. Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administration, and seven related to the GH/IGF-1 effect on bone healing. Results. Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies. GH/IGF-1 administration in patients with hip or tibial fractures resulted in increased bone healing, rapid clinical improvements. Some conflicting results were evidenced. Conclusions. GH and IGF-1 therapy has a significant anabolic effect. GH administration for the treatment of osteoporosis and bone fractures may greatly improve clinical outcome. GH interacts with sex steroids in the anabolic process. GH resistance process is considered. Hindawi Publishing Corporation 2014 2014-07-23 /pmc/articles/PMC4132406/ /pubmed/25147565 http://dx.doi.org/10.1155/2014/235060 Text en Copyright © 2014 V. Locatelli and V. E. Bianchi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Locatelli, Vittorio
Bianchi, Vittorio E.
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
title Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
title_full Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
title_fullStr Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
title_full_unstemmed Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
title_short Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
title_sort effect of gh/igf-1 on bone metabolism and osteoporsosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132406/
https://www.ncbi.nlm.nih.gov/pubmed/25147565
http://dx.doi.org/10.1155/2014/235060
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