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A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions

PURPOSE: A newly isolated mediastinal lymph node (LN) or a small pulmonary nodule, which appears during breast cancer surveillance, may pose a diagnostic dilemma with regard to malignancy. We conducted this study to determine which clinical factors were useful for the differentiation of malignant le...

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Autores principales: Kim, Tae-Yong, Lee, Kyung-Hun, Han, Sae-Won, Oh, Do-Youn, Im, Seock-Ah, Kim, Tae-You, Han, Wonshik, Kim, Kyubo, Chie, Eui Kyu, Park, In-Ae, Kim, Young Tae, Noh, Dong-Young, Ha, Sung Whan, Bang, Yung-Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132446/
https://www.ncbi.nlm.nih.gov/pubmed/25038763
http://dx.doi.org/10.4143/crt.2014.46.3.280
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author Kim, Tae-Yong
Lee, Kyung-Hun
Han, Sae-Won
Oh, Do-Youn
Im, Seock-Ah
Kim, Tae-You
Han, Wonshik
Kim, Kyubo
Chie, Eui Kyu
Park, In-Ae
Kim, Young Tae
Noh, Dong-Young
Ha, Sung Whan
Bang, Yung-Jue
author_facet Kim, Tae-Yong
Lee, Kyung-Hun
Han, Sae-Won
Oh, Do-Youn
Im, Seock-Ah
Kim, Tae-You
Han, Wonshik
Kim, Kyubo
Chie, Eui Kyu
Park, In-Ae
Kim, Young Tae
Noh, Dong-Young
Ha, Sung Whan
Bang, Yung-Jue
author_sort Kim, Tae-Yong
collection PubMed
description PURPOSE: A newly isolated mediastinal lymph node (LN) or a small pulmonary nodule, which appears during breast cancer surveillance, may pose a diagnostic dilemma with regard to malignancy. We conducted this study to determine which clinical factors were useful for the differentiation of malignant lesions from benign lesions under these circumstances. MATERIALS AND METHODS: We enrolled breast cancer patients who were presented with a new isolated mediastinal LN or small pulmonary nodule that arose during surveillance, and whose lesions were pathologically confirmed. Tissue diagnosis was made by mediastinoscopy, video-assisted thoracic surgery or thoracotomy. RESULTS: A total of 43 patients were enrolled (mediastinal LN, 13 patients; pulmonary nodule, 30 patients). Eighteen patients (41.9%) were pathologically confirmed to have a benign lesion (benign group), and 25 patients (58.1%) were confirmed to have malignant lesion (malignant group). Between the two groups, the initial tumor size (p=0.096) and N stage (p=0.749) were similar. Hormone receptor negativity was more prevalent in the malignant group (59.1% vs. 40.9%, p=0.048). The mean lesion size was larger in the malignant group than in the benign group (20.8 mm vs. 14.4 mm, p=0.024). Metastatic lesions had a significantly higher value of maximal standardized uptake (mSUV) than that of benign lesions (6.4 vs. 3.4, p=0.021). CONCLUSION: Hormone receptor status, lesion size, and mSUV on positron emission tomography are helpful in the differentiation of malignant lesions from benign lesions in breast cancer patients who were presented with a new isolated mediastinal LN or small pulmonary nodule during surveillance.
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spelling pubmed-41324462014-08-20 A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions Kim, Tae-Yong Lee, Kyung-Hun Han, Sae-Won Oh, Do-Youn Im, Seock-Ah Kim, Tae-You Han, Wonshik Kim, Kyubo Chie, Eui Kyu Park, In-Ae Kim, Young Tae Noh, Dong-Young Ha, Sung Whan Bang, Yung-Jue Cancer Res Treat Original Article PURPOSE: A newly isolated mediastinal lymph node (LN) or a small pulmonary nodule, which appears during breast cancer surveillance, may pose a diagnostic dilemma with regard to malignancy. We conducted this study to determine which clinical factors were useful for the differentiation of malignant lesions from benign lesions under these circumstances. MATERIALS AND METHODS: We enrolled breast cancer patients who were presented with a new isolated mediastinal LN or small pulmonary nodule that arose during surveillance, and whose lesions were pathologically confirmed. Tissue diagnosis was made by mediastinoscopy, video-assisted thoracic surgery or thoracotomy. RESULTS: A total of 43 patients were enrolled (mediastinal LN, 13 patients; pulmonary nodule, 30 patients). Eighteen patients (41.9%) were pathologically confirmed to have a benign lesion (benign group), and 25 patients (58.1%) were confirmed to have malignant lesion (malignant group). Between the two groups, the initial tumor size (p=0.096) and N stage (p=0.749) were similar. Hormone receptor negativity was more prevalent in the malignant group (59.1% vs. 40.9%, p=0.048). The mean lesion size was larger in the malignant group than in the benign group (20.8 mm vs. 14.4 mm, p=0.024). Metastatic lesions had a significantly higher value of maximal standardized uptake (mSUV) than that of benign lesions (6.4 vs. 3.4, p=0.021). CONCLUSION: Hormone receptor status, lesion size, and mSUV on positron emission tomography are helpful in the differentiation of malignant lesions from benign lesions in breast cancer patients who were presented with a new isolated mediastinal LN or small pulmonary nodule during surveillance. Korean Cancer Association 2014-07 2014-07-15 /pmc/articles/PMC4132446/ /pubmed/25038763 http://dx.doi.org/10.4143/crt.2014.46.3.280 Text en Copyright © 2014 by the Korean Cancer Association This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Tae-Yong
Lee, Kyung-Hun
Han, Sae-Won
Oh, Do-Youn
Im, Seock-Ah
Kim, Tae-You
Han, Wonshik
Kim, Kyubo
Chie, Eui Kyu
Park, In-Ae
Kim, Young Tae
Noh, Dong-Young
Ha, Sung Whan
Bang, Yung-Jue
A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions
title A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions
title_full A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions
title_fullStr A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions
title_full_unstemmed A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions
title_short A New Isolated Mediastinal Lymph Node or Small Pulmonary Nodule Arising during Breast Cancer Surveillance Following Curative Surgery: Clinical Factors That Differentiate Malignant from Benign Lesions
title_sort new isolated mediastinal lymph node or small pulmonary nodule arising during breast cancer surveillance following curative surgery: clinical factors that differentiate malignant from benign lesions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132446/
https://www.ncbi.nlm.nih.gov/pubmed/25038763
http://dx.doi.org/10.4143/crt.2014.46.3.280
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