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Slow repair of lipid peroxidation-induced DNA damage at p53 mutation hotspots in human cells caused by low turnover of a DNA glycosylase

Repair of oxidative stress- and inflammation-induced DNA lesions by the base excision repair (BER) pathway prevents mutation, a form of genomic instability which is often observed in cancer as ‘mutation hotspots’. This suggests that some sequences have inherent mutability, possibly due to sequence-r...

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Detalles Bibliográficos
Autores principales:	Woodrick, Jordan, Gupta, Suhani, Khatkar, Pooja, Sarangi, Sanchita, Narasimhan, Ganga, Trehan, Akriti, Adhikari, Sanjay, Roy, Rabindra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132702/ https://www.ncbi.nlm.nih.gov/pubmed/25081213 http://dx.doi.org/10.1093/nar/gku520

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