DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

We previously identified the heterogeneous ribonucleoprotein SAF-A/hnRNP U as a substrate for DNA-PK, a protein kinase involved in DNA damage response (DDR). Using laser micro-irradiation in human cells, we report here that SAF-A exhibits a two-phase dynamics at sites of DNA damage, with a rapid and...

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Detalles Bibliográficos
Autores principales: Britton, Sébastien, Dernoncourt, Emma, Delteil, Christine, Froment, Carine, Schiltz, Odile, Salles, Bernard, Frit, Philippe, Calsou, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132723/
https://www.ncbi.nlm.nih.gov/pubmed/25030905
http://dx.doi.org/10.1093/nar/gku601

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