FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers

Genetic recombination is important for generating diversity and to ensure faithful segregation of chromosomes at meiosis. However, few crossovers (COs) are formed per meiosis despite an excess of DNA double-strand break precursors. This reflects the existence of active mechanisms that limit CO forma...

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Detalles Bibliográficos
Autores principales: Girard, Chloe, Crismani, Wayne, Froger, Nicole, Mazel, Julien, Lemhemdi, Afef, Horlow, Christine, Mercier, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132730/
https://www.ncbi.nlm.nih.gov/pubmed/25038251
http://dx.doi.org/10.1093/nar/gku614

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