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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Decitabine (5-aza-2′-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in differentiation and transformation, as well as induction of DNA damage by trappin...

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Detalles Bibliográficos
Autores principales:	Orta, Manuel Luis, Höglund, Andreas, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Burgos-Morón, Estefanía, Visnes, Torkild, Pastor, Nuria, Ström, Cecilia, López-lázaro, Miguel, Helleday, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132747/ https://www.ncbi.nlm.nih.gov/pubmed/25074383 http://dx.doi.org/10.1093/nar/gku638

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