Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site

Human topoisomerase 1B has been simulated covalently bound to a negatively supercoiled DNA minicircle, and its behavior compared to the enzyme bound to a simple linear DNA duplex. The presence of the more realistic supercoiled substrate facilitates the formation of larger number of protein–DNA inter...

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Detalles Bibliográficos
Autores principales: D'Annessa, Ilda, Coletta, Andrea, Sutthibutpong, Thana, Mitchell, Jonathan, Chillemi, Giovanni, Harris, Sarah, Desideri, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132758/
https://www.ncbi.nlm.nih.gov/pubmed/25056319
http://dx.doi.org/10.1093/nar/gku654

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