5′ isomiR variation is of functional and evolutionary importance

We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3′ and/or 5′ end of the miRNA. Northern blotting for individual miRNAs showed that the prop...

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Detalles Bibliográficos
Autores principales: Tan, Geok Chin, Chan, Elcie, Molnar, Attila, Sarkar, Rupa, Alexieva, Diana, Isa, Ihsan Mad, Robinson, Sophie, Zhang, Shuchen, Ellis, Peter, Langford, Cordelia F., Guillot, Pascale V., Chandrashekran, Anil, Fisk, Nick M., Castellano, Leandro, Meister, Gunter, Winston, Robert M., Cui, Wei, Baulcombe, David, Dibb, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132760/
https://www.ncbi.nlm.nih.gov/pubmed/25056318
http://dx.doi.org/10.1093/nar/gku656

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