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High-Throughput and Combinatorial Gene Expression on a Chip for Metabolism-Induced Toxicology Screening
Differential expression of various drug-metabolizing enzymes in the human liver may cause deviations of pharmacokinetic profiles, resulting in inter-individual variability of drug toxicity and/or efficacy. Here we present the “Transfected Enzyme and Metabolism Chip” (TeamChip), which predicts potent...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132844/ https://www.ncbi.nlm.nih.gov/pubmed/24799042 http://dx.doi.org/10.1038/ncomms4739 |