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Quantifying the Sources of Kinetic Frustration in Folding Simulations of Small Proteins
[Image: see text] Experiments and atomistic simulations of polypeptides have revealed structural intermediates that promote or inhibit conformational transitions to the native state during folding. We invoke a concept of “kinetic frustration” to quantify the prevalence and impact of these behaviors...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132847/ https://www.ncbi.nlm.nih.gov/pubmed/25136267 http://dx.doi.org/10.1021/ct500361w |