Cargando…

Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue

We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using li...

Descripción completa

Detalles Bibliográficos
Autores principales: Valdes, Claudia P., Varma, Hari M., Kristoffersen, Anna K., Dragojevic, Tanja, Culver, Joseph P., Durduran, Turgut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133004/
https://www.ncbi.nlm.nih.gov/pubmed/25136500
http://dx.doi.org/10.1364/BOE.5.002769
Descripción
Sumario:We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.