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Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue

We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using li...

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Detalles Bibliográficos
Autores principales: Valdes, Claudia P., Varma, Hari M., Kristoffersen, Anna K., Dragojevic, Tanja, Culver, Joseph P., Durduran, Turgut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133004/
https://www.ncbi.nlm.nih.gov/pubmed/25136500
http://dx.doi.org/10.1364/BOE.5.002769
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author Valdes, Claudia P.
Varma, Hari M.
Kristoffersen, Anna K.
Dragojevic, Tanja
Culver, Joseph P.
Durduran, Turgut
author_facet Valdes, Claudia P.
Varma, Hari M.
Kristoffersen, Anna K.
Dragojevic, Tanja
Culver, Joseph P.
Durduran, Turgut
author_sort Valdes, Claudia P.
collection PubMed
description We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.
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spelling pubmed-41330042014-08-18 Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue Valdes, Claudia P. Varma, Hari M. Kristoffersen, Anna K. Dragojevic, Tanja Culver, Joseph P. Durduran, Turgut Biomed Opt Express Article We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises. Optical Society of America 2014-07-23 /pmc/articles/PMC4133004/ /pubmed/25136500 http://dx.doi.org/10.1364/BOE.5.002769 Text en © 2014 Optical Society of America author-open
spellingShingle Article
Valdes, Claudia P.
Varma, Hari M.
Kristoffersen, Anna K.
Dragojevic, Tanja
Culver, Joseph P.
Durduran, Turgut
Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
title Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
title_full Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
title_fullStr Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
title_full_unstemmed Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
title_short Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
title_sort speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133004/
https://www.ncbi.nlm.nih.gov/pubmed/25136500
http://dx.doi.org/10.1364/BOE.5.002769
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