Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report

The treatment for AML (Acute myeloid/myelogenous leukemia) transformed from MDS (myelodysplastic syndrome) is difficult and controversial clinically, especially in elder patients. In this case report, we diagnosed a 59-year-old female patient with AML-M2a transformed form MDS which might be caused b...

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Detalles Bibliográficos
Autores principales: Wang, Jin, Liu, Yu, Zhou, Xu, Li, Zheng, Li, Xiang, Xiao, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133025/
https://www.ncbi.nlm.nih.gov/pubmed/24696077
http://dx.doi.org/10.1007/s12013-014-9926-3
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author Wang, Jin
Liu, Yu
Zhou, Xu
Li, Zheng
Li, Xiang
Xiao, Hualiang
author_facet Wang, Jin
Liu, Yu
Zhou, Xu
Li, Zheng
Li, Xiang
Xiao, Hualiang
author_sort Wang, Jin
collection PubMed
description The treatment for AML (Acute myeloid/myelogenous leukemia) transformed from MDS (myelodysplastic syndrome) is difficult and controversial clinically, especially in elder patients. In this case report, we diagnosed a 59-year-old female patient with AML-M2a transformed form MDS which might be caused by her chemotherapy for mastocarcinoma. After achieving complete remission (CR) through combined chemotherapy, autologous peripheral blood stem cell transplantation (auto-PBSCT) was attempted. Following auto-HSCT, marrow showed continuous CR but the patient later developed extramedullary bone-infiltration relapse. Then local radiotherapy has been applied, and the patient now has prolonged survival. This is the first (or a successful) case report of auto-HSCT in an elderly patient with AML transformed from MDS.
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spelling pubmed-41330252014-08-21 Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report Wang, Jin Liu, Yu Zhou, Xu Li, Zheng Li, Xiang Xiao, Hualiang Cell Biochem Biophys Original Paper The treatment for AML (Acute myeloid/myelogenous leukemia) transformed from MDS (myelodysplastic syndrome) is difficult and controversial clinically, especially in elder patients. In this case report, we diagnosed a 59-year-old female patient with AML-M2a transformed form MDS which might be caused by her chemotherapy for mastocarcinoma. After achieving complete remission (CR) through combined chemotherapy, autologous peripheral blood stem cell transplantation (auto-PBSCT) was attempted. Following auto-HSCT, marrow showed continuous CR but the patient later developed extramedullary bone-infiltration relapse. Then local radiotherapy has been applied, and the patient now has prolonged survival. This is the first (or a successful) case report of auto-HSCT in an elderly patient with AML transformed from MDS. Springer US 2014-04-03 2014 /pmc/articles/PMC4133025/ /pubmed/24696077 http://dx.doi.org/10.1007/s12013-014-9926-3 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Wang, Jin
Liu, Yu
Zhou, Xu
Li, Zheng
Li, Xiang
Xiao, Hualiang
Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report
title Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report
title_full Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report
title_fullStr Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report
title_full_unstemmed Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report
title_short Extramedullary Relapse of the AML Transformed from MDS Following Auto-HSCT: A Case Report
title_sort extramedullary relapse of the aml transformed from mds following auto-hsct: a case report
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133025/
https://www.ncbi.nlm.nih.gov/pubmed/24696077
http://dx.doi.org/10.1007/s12013-014-9926-3
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