Oridonin Attenuates Aβ(1–42)-Induced Neuroinflammation and Inhibits NF-κB Pathway

Neuroinflammation induced by beta-amyloid (Aβ) plays a critical role in the pathogenesis of Alzheimer’s disease (AD), and inhibiting Aβ-induced neuroinflammation serves as a potential strategy for the treatment of AD. Oridonin (Ori), a compound of Rabdosia rubescens, has been shown to exert anti-inflammatory effects. In this study, we demonstrated that Ori inhibited glial activation and decreased the release of inflammatory cytokines in the hippocampus of Aβ(1–42)-induced AD mice. In addition, Ori inhibited the NF-κB pathway and Aβ(1–42)-induced apoptosis. Furthermore, Ori could attenuate memory deficits in Aβ(1–42)-induced AD mice. In conclusion, our study demonstrated that Ori inhibited the neuroinflammation and attenuated memory deficits induced by Aβ(1–42), suggesting that Ori might be a promising candidate for AD treatment.