Distinct APC Subtypes Drive Spatially Segregated CD4(+) and CD8(+) T-Cell Effector Activity during Skin Infection with HSV-1

Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell effector function in situ remains poorly understood. Here, we show key differences in the regulation of effector activity between CD4(+) and CD8(+) T-cells during skin inf...

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Detalles Bibliográficos
Autores principales: Macleod, Bethany L., Bedoui, Sammy, Hor, Jyh Liang, Mueller, Scott N., Russell, Tiffany A., Hollett, Natasha A., Heath, William R., Tscharke, David C., Brooks, Andrew G., Gebhardt, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133397/
https://www.ncbi.nlm.nih.gov/pubmed/25121482
http://dx.doi.org/10.1371/journal.ppat.1004303

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