Activation of Cdc42 is necessary for sustained oscillations of Ca(2+) and PIP(2) stimulated by antigen in RBL mast cells

Antigen stimulation of mast cells via FcεRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during the allergic response. To characterize the role of Rho GTPases in FcεRI signaling, we utilized a mutant RBL cell...

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Detalles Bibliográficos
Autores principales: Wilkes, Marcus M., Wilson, Joshua D., Baird, Barbara, Holowka, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133723/
https://www.ncbi.nlm.nih.gov/pubmed/24996924
http://dx.doi.org/10.1242/bio.20148862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133723/
https://www.ncbi.nlm.nih.gov/pubmed/24996924
http://dx.doi.org/10.1242/bio.20148862

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