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HER2 induces expression of leptin in human breast epithelial cells
A close association between the obesity hormone leptin and breast cancer progression has been suggested. The present study investigated the molecular mechanism for enhanced leptin expression in breast cancer cells and its functional significance in breast cancer aggressiveness. We examined whether l...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133819/ https://www.ncbi.nlm.nih.gov/pubmed/23261058 http://dx.doi.org/10.5483/BMBRep.2012.45.12.164 |
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author | Cha, Yujin Kang, Youjin Moon, Aree |
author_facet | Cha, Yujin Kang, Youjin Moon, Aree |
author_sort | Cha, Yujin |
collection | PubMed |
description | A close association between the obesity hormone leptin and breast cancer progression has been suggested. The present study investigated the molecular mechanism for enhanced leptin expression in breast cancer cells and its functional significance in breast cancer aggressiveness. We examined whether leptin expression level is affected by the oncoprotein human epidermal growth factor receptor2 (HER2), which is overexpressed in ∼30% of breast tumors. Here, we report, for the first time, that HER2 induces transcriptional activation of leptin in MCF10A human breast epithelial cells. We also showed that p38 mitogen-activated protein kinase signaling was involved in leptin expression induced by HER2. We showed a crucial role of leptin in the invasiveness of HER2-MCF10A cells using an siRNA molecule targeting leptin. Taken together, the results indicate a molecular link between HER2 and leptin, providing supporting evidence that leptin represents a target for breast cancer therapy. [BMB Reports 2012; 45(12): 719-723] |
format | Online Article Text |
id | pubmed-4133819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-41338192014-09-16 HER2 induces expression of leptin in human breast epithelial cells Cha, Yujin Kang, Youjin Moon, Aree BMB Rep Research Articles A close association between the obesity hormone leptin and breast cancer progression has been suggested. The present study investigated the molecular mechanism for enhanced leptin expression in breast cancer cells and its functional significance in breast cancer aggressiveness. We examined whether leptin expression level is affected by the oncoprotein human epidermal growth factor receptor2 (HER2), which is overexpressed in ∼30% of breast tumors. Here, we report, for the first time, that HER2 induces transcriptional activation of leptin in MCF10A human breast epithelial cells. We also showed that p38 mitogen-activated protein kinase signaling was involved in leptin expression induced by HER2. We showed a crucial role of leptin in the invasiveness of HER2-MCF10A cells using an siRNA molecule targeting leptin. Taken together, the results indicate a molecular link between HER2 and leptin, providing supporting evidence that leptin represents a target for breast cancer therapy. [BMB Reports 2012; 45(12): 719-723] Korean Society for Biochemistry and Molecular Biology 2012-12 /pmc/articles/PMC4133819/ /pubmed/23261058 http://dx.doi.org/10.5483/BMBRep.2012.45.12.164 Text en Copyright © 2012, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Cha, Yujin Kang, Youjin Moon, Aree HER2 induces expression of leptin in human breast epithelial cells |
title | HER2 induces expression of leptin in human breast epithelial cells |
title_full | HER2 induces expression of leptin in human breast epithelial cells |
title_fullStr | HER2 induces expression of leptin in human breast epithelial cells |
title_full_unstemmed | HER2 induces expression of leptin in human breast epithelial cells |
title_short | HER2 induces expression of leptin in human breast epithelial cells |
title_sort | her2 induces expression of leptin in human breast epithelial cells |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133819/ https://www.ncbi.nlm.nih.gov/pubmed/23261058 http://dx.doi.org/10.5483/BMBRep.2012.45.12.164 |
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