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When a ribosome encounters a premature termination codon

In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mamm...

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Detalles Bibliográficos
Autores principales:	Hwang, Jungwook, Kim, Yoon Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2013
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133823/ https://www.ncbi.nlm.nih.gov/pubmed/23351378 http://dx.doi.org/10.5483/BMBRep.2013.46.1.002

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