Altered sugar donor specificity and catalytic activity of pteridine glycosyltransferases by domain swapping or site-directed mutagenesis

CY-007 and CY-049 pteridine glycosyltransferases (PGTs) that differ in sugar donor specificity to catalyze either glucose or xylose transfer to tetrahydrobiopterin were studied here to uncover the structural determinants necessary for the specificity. The importance of the C-terminal domain and its...

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Detalles Bibliográficos
Autores principales: Kim, Hye-Lim, Kim, Ae Hyun, Park, Mi Bi, Lee, Soo-Woong, Park, Young Shik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133829/
https://www.ncbi.nlm.nih.gov/pubmed/23351382
http://dx.doi.org/10.5483/BMBRep.2013.46.1.147

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