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Impact of tumour associated macrophages in pancreatic cancer
During cancer progression, bone marrow derived myeloid cells, including immature myeloid cells and macrophages, progressively accumulate at the primary tumour site where they contribute to the establishment of a tumour promoting microenvironment. A marked infiltration of macrophages into the stromal...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133870/ https://www.ncbi.nlm.nih.gov/pubmed/23527856 http://dx.doi.org/10.5483/BMBRep.2013.46.3.036 |
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author | Mielgo, Ainhoa Schmid, Michael C. |
author_facet | Mielgo, Ainhoa Schmid, Michael C. |
author_sort | Mielgo, Ainhoa |
collection | PubMed |
description | During cancer progression, bone marrow derived myeloid cells, including immature myeloid cells and macrophages, progressively accumulate at the primary tumour site where they contribute to the establishment of a tumour promoting microenvironment. A marked infiltration of macrophages into the stromal compartment and the generation of a desmoplastic stromal reaction is a particular characteristic of pancreatic ductal adenocarcinoma (PDA) and is thought to play a key role in disease progression and its response to therapy. Tumour associated macrophages (TAMs) foster PDA tumour progression by promoting angiogenesis, metastasis, and by suppressing an anti-tumourigenic immune response. Recent work also suggests that TAMs contribute to resistance to chemotherapy and to the emergence of cancer stem-like cells. Here we will review the current understanding of the biology and the pro-tumourigenic functions of TAMs in cancer and specifically in PDA, and highlight potential therapeutic strategies to target TAMs and to improve current therapies for pancreatic cancer. [BMB Reports 2013; 46(3): 131-138] |
format | Online Article Text |
id | pubmed-4133870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-41338702014-09-16 Impact of tumour associated macrophages in pancreatic cancer Mielgo, Ainhoa Schmid, Michael C. BMB Rep Research Articles During cancer progression, bone marrow derived myeloid cells, including immature myeloid cells and macrophages, progressively accumulate at the primary tumour site where they contribute to the establishment of a tumour promoting microenvironment. A marked infiltration of macrophages into the stromal compartment and the generation of a desmoplastic stromal reaction is a particular characteristic of pancreatic ductal adenocarcinoma (PDA) and is thought to play a key role in disease progression and its response to therapy. Tumour associated macrophages (TAMs) foster PDA tumour progression by promoting angiogenesis, metastasis, and by suppressing an anti-tumourigenic immune response. Recent work also suggests that TAMs contribute to resistance to chemotherapy and to the emergence of cancer stem-like cells. Here we will review the current understanding of the biology and the pro-tumourigenic functions of TAMs in cancer and specifically in PDA, and highlight potential therapeutic strategies to target TAMs and to improve current therapies for pancreatic cancer. [BMB Reports 2013; 46(3): 131-138] Korean Society for Biochemistry and Molecular Biology 2013-03 /pmc/articles/PMC4133870/ /pubmed/23527856 http://dx.doi.org/10.5483/BMBRep.2013.46.3.036 Text en Copyright © 2013, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Mielgo, Ainhoa Schmid, Michael C. Impact of tumour associated macrophages in pancreatic cancer |
title | Impact of tumour associated macrophages in pancreatic cancer |
title_full | Impact of tumour associated macrophages in pancreatic cancer |
title_fullStr | Impact of tumour associated macrophages in pancreatic cancer |
title_full_unstemmed | Impact of tumour associated macrophages in pancreatic cancer |
title_short | Impact of tumour associated macrophages in pancreatic cancer |
title_sort | impact of tumour associated macrophages in pancreatic cancer |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133870/ https://www.ncbi.nlm.nih.gov/pubmed/23527856 http://dx.doi.org/10.5483/BMBRep.2013.46.3.036 |
work_keys_str_mv | AT mielgoainhoa impactoftumourassociatedmacrophagesinpancreaticcancer AT schmidmichaelc impactoftumourassociatedmacrophagesinpancreaticcancer |