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Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation

Human α-galactosidase A (GLA) has been used in enzyme replacement therapy for patients with Fabry disease. We expressed recombinant GLA from Chinese hamster ovary cells with very high productivity. When compared to an approved GLA (agalsidase beta), its size and charge were found to be smaller and m...

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Detalles Bibliográficos
Autores principales:	Sohn, Youngsoo, Lee, Jung Mi, Park, Heung-Rok, Jung, Sung-Chul, Park, Tai Hyun, Oh, Doo-Byoung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133871/ https://www.ncbi.nlm.nih.gov/pubmed/23527859 http://dx.doi.org/10.5483/BMBRep.2013.46.3.192

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