Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In...

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Autores principales: Shin, Hyoseung, Yoo, Hyeon Gyeong, Inui, Shigeki, Itami, Satoshi, Kim, In Gyu, Cho, A-Ri, Lee, Dong Hun, Park, Won Seok, Kwon, Ohsang, Cho, Kwang Hyun, Won, Chong Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133876/
https://www.ncbi.nlm.nih.gov/pubmed/24064061
http://dx.doi.org/10.5483/BMBRep.2013.46.9.228
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author Shin, Hyoseung
Yoo, Hyeon Gyeong
Inui, Shigeki
Itami, Satoshi
Kim, In Gyu
Cho, A-Ri
Lee, Dong Hun
Park, Won Seok
Kwon, Ohsang
Cho, Kwang Hyun
Won, Chong Hyun
author_facet Shin, Hyoseung
Yoo, Hyeon Gyeong
Inui, Shigeki
Itami, Satoshi
Kim, In Gyu
Cho, A-Ri
Lee, Dong Hun
Park, Won Seok
Kwon, Ohsang
Cho, Kwang Hyun
Won, Chong Hyun
author_sort Shin, Hyoseung
collection PubMed
description The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgeninducible TGF-β1 was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs. [BMB Reports 2013; 46(9): 460-464]
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spelling pubmed-41338762014-09-16 Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells Shin, Hyoseung Yoo, Hyeon Gyeong Inui, Shigeki Itami, Satoshi Kim, In Gyu Cho, A-Ri Lee, Dong Hun Park, Won Seok Kwon, Ohsang Cho, Kwang Hyun Won, Chong Hyun BMB Rep Research Articles The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgeninducible TGF-β1 was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs. [BMB Reports 2013; 46(9): 460-464] Korean Society for Biochemistry and Molecular Biology 2013-09 /pmc/articles/PMC4133876/ /pubmed/24064061 http://dx.doi.org/10.5483/BMBRep.2013.46.9.228 Text en Copyright © 2013, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Shin, Hyoseung
Yoo, Hyeon Gyeong
Inui, Shigeki
Itami, Satoshi
Kim, In Gyu
Cho, A-Ri
Lee, Dong Hun
Park, Won Seok
Kwon, Ohsang
Cho, Kwang Hyun
Won, Chong Hyun
Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
title Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
title_full Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
title_fullStr Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
title_full_unstemmed Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
title_short Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
title_sort induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133876/
https://www.ncbi.nlm.nih.gov/pubmed/24064061
http://dx.doi.org/10.5483/BMBRep.2013.46.9.228
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