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The uniqueness of the plant mitochondrial potassium channel

The ATP-inhibited Plant Mitochondrial K(+) Channel (PmitoK(ATP)) was discovered about fifteen years ago in Durum Wheat Mitochondria (DWM). PmitoKATP catalyses the electrophoretic K(+) uniport through the inner mitochondrial membrane; moreover, the co-operation between PmitoK(ATP) and (+)/H(+) antipo...

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Detalles Bibliográficos
Autores principales: Pastore, Donato, Soccio, Mario, Laus, Maura Nicoletta, Trono, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133908/
https://www.ncbi.nlm.nih.gov/pubmed/23977986
http://dx.doi.org/10.5483/BMBRep.2013.46.8.075
Descripción
Sumario:The ATP-inhibited Plant Mitochondrial K(+) Channel (PmitoK(ATP)) was discovered about fifteen years ago in Durum Wheat Mitochondria (DWM). PmitoKATP catalyses the electrophoretic K(+) uniport through the inner mitochondrial membrane; moreover, the co-operation between PmitoK(ATP) and (+)/H(+) antiporter allows such a great operation of a K(+) cycle to collapse mitochondrial membrane potential (ΔΨ) and ΔpH, thus impairing protonmotive force (Δp). A possible physiological role of such ΔΨ control is the restriction of harmful reactive oxygen species (ROS) production under environmental/oxidative stress conditions. Interestingly, DWM lacking Δp were found to be nevertheless fully coupled and able to regularly accomplish ATP synthesis; this unexpected behaviour makes necessary to recast in some way the classical chemiosmotic model. In the whole, PmitoK(ATP) may oppose to large scale ROS production by lowering ΔΨ under environmental/oxidative stress, but, when stress is moderate, this occurs without impairing ATP synthesis in a crucial moment for cell and mitochondrial bioenergetics. [BMB Reports 2013; 46(8): 391-397]