Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in...

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Detalles Bibliográficos
Autores principales: Cronin, Robert M., Field, Julie R., Bradford, Yuki, Shaffer, Christian M., Carroll, Robert J., Mosley, Jonathan D., Bastarache, Lisa, Edwards, Todd L., Hebbring, Scott J., Lin, Simon, Hindorff, Lucia A., Crane, Paul K., Pendergrass, Sarah A., Ritchie, Marylyn D., Crawford, Dana C., Pathak, Jyotishman, Bielinski, Suzette J., Carrell, David S., Crosslin, David R., Ledbetter, David H., Carey, David J., Tromp, Gerard, Williams, Marc S., Larson, Eric B., Jarvik, Gail P., Peissig, Peggy L., Brilliant, Murray H., McCarty, Catherine A., Chute, Christopher G., Kullo, Iftikhar J., Bottinger, Erwin, Chisholm, Rex, Smith, Maureen E., Roden, Dan M., Denny, Joshua C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134007/
https://www.ncbi.nlm.nih.gov/pubmed/25177340
http://dx.doi.org/10.3389/fgene.2014.00250

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