A clinical perspective on the role of chronic inflammation in gastrointestinal cancer

Chronic inflammation has been identified as an important risk factor for the development of malignancy, and knowledge about its molecular and cellular mechanisms is increasing. Several chronic inflammatory diseases of the gastrointestinal tract are important as risk factors for malignancy and have b...

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Autores principales: Rasch, Sebastian, Algül, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134025/
https://www.ncbi.nlm.nih.gov/pubmed/25143751
http://dx.doi.org/10.2147/CEG.S43457
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author Rasch, Sebastian
Algül, Hana
author_facet Rasch, Sebastian
Algül, Hana
author_sort Rasch, Sebastian
collection PubMed
description Chronic inflammation has been identified as an important risk factor for the development of malignancy, and knowledge about its molecular and cellular mechanisms is increasing. Several chronic inflammatory diseases of the gastrointestinal tract are important as risk factors for malignancy and have been studied in detail. In this review, we summarize important molecular mechanisms in chronic inflammation and highlight established and potential links between chronic inflammation and gastrointestinal cancer. In addition, we present the role of chronic inflammation in numerous tumors within the gastrointestinal tract as well as the relevant pathways or epidemiologic observations linking the pathogenesis of these tumors to inflammation.
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spelling pubmed-41340252014-08-20 A clinical perspective on the role of chronic inflammation in gastrointestinal cancer Rasch, Sebastian Algül, Hana Clin Exp Gastroenterol Review Chronic inflammation has been identified as an important risk factor for the development of malignancy, and knowledge about its molecular and cellular mechanisms is increasing. Several chronic inflammatory diseases of the gastrointestinal tract are important as risk factors for malignancy and have been studied in detail. In this review, we summarize important molecular mechanisms in chronic inflammation and highlight established and potential links between chronic inflammation and gastrointestinal cancer. In addition, we present the role of chronic inflammation in numerous tumors within the gastrointestinal tract as well as the relevant pathways or epidemiologic observations linking the pathogenesis of these tumors to inflammation. Dove Medical Press 2014-08-11 /pmc/articles/PMC4134025/ /pubmed/25143751 http://dx.doi.org/10.2147/CEG.S43457 Text en © 2014 Rasch and Algül. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Rasch, Sebastian
Algül, Hana
A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
title A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
title_full A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
title_fullStr A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
title_full_unstemmed A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
title_short A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
title_sort clinical perspective on the role of chronic inflammation in gastrointestinal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134025/
https://www.ncbi.nlm.nih.gov/pubmed/25143751
http://dx.doi.org/10.2147/CEG.S43457
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