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Systemic RNAi Delivery to the Muscles of ROSA26 Mice Reduces lacZ Expression
RNAi has potential for therapeutically downregulating the expression of dominantly inherited genes in a variety of human genetic disorders. Here we used the ROSA26 mouse, which constitutively expresses the bacterial lacZ gene in tissues body wide, as a model to test the ability to downregulate gene...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134137/ https://www.ncbi.nlm.nih.gov/pubmed/25127128 http://dx.doi.org/10.1371/journal.pone.0102053 |