Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption

[Image: see text] Ultrasmall glutathione-coated luminescent gold nanoparticles (GS-AuNPs) are known for their high resistance to serum protein adsorption. Our studies show that these NPs can serve as surface ligands to significantly enhance the physiological stability and lower the serum protein ads...

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Autores principales: Vinluan, Rodrigo D., Liu, Jinbin, Zhou, Chen, Yu, Mengxiao, Yang, Shengyang, Kumar, Amit, Sun, Shasha, Dean, Andrew, Sun, Xiankai, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134186/
https://www.ncbi.nlm.nih.gov/pubmed/25029478
http://dx.doi.org/10.1021/am5031374
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author Vinluan, Rodrigo D.
Liu, Jinbin
Zhou, Chen
Yu, Mengxiao
Yang, Shengyang
Kumar, Amit
Sun, Shasha
Dean, Andrew
Sun, Xiankai
Zheng, Jie
author_facet Vinluan, Rodrigo D.
Liu, Jinbin
Zhou, Chen
Yu, Mengxiao
Yang, Shengyang
Kumar, Amit
Sun, Shasha
Dean, Andrew
Sun, Xiankai
Zheng, Jie
author_sort Vinluan, Rodrigo D.
collection PubMed
description [Image: see text] Ultrasmall glutathione-coated luminescent gold nanoparticles (GS-AuNPs) are known for their high resistance to serum protein adsorption. Our studies show that these NPs can serve as surface ligands to significantly enhance the physiological stability and lower the serum protein adsorption of superparamagnetic iron oxide nanoparticles (SPIONs), in addition to rendering the NPs the luminescence property. After the incorporation of GS-AuNPs onto the surface of SPIONs to form the hybrid nanoparticles (HBNPs), these SPIONs’ protein adsorption was about 10-fold lower than those of the pure glutathione-coated SPIONs suggesting that GS-AuNPs are capable of providing a stealth effect against serum proteins.
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spelling pubmed-41341862015-07-16 Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption Vinluan, Rodrigo D. Liu, Jinbin Zhou, Chen Yu, Mengxiao Yang, Shengyang Kumar, Amit Sun, Shasha Dean, Andrew Sun, Xiankai Zheng, Jie ACS Appl Mater Interfaces [Image: see text] Ultrasmall glutathione-coated luminescent gold nanoparticles (GS-AuNPs) are known for their high resistance to serum protein adsorption. Our studies show that these NPs can serve as surface ligands to significantly enhance the physiological stability and lower the serum protein adsorption of superparamagnetic iron oxide nanoparticles (SPIONs), in addition to rendering the NPs the luminescence property. After the incorporation of GS-AuNPs onto the surface of SPIONs to form the hybrid nanoparticles (HBNPs), these SPIONs’ protein adsorption was about 10-fold lower than those of the pure glutathione-coated SPIONs suggesting that GS-AuNPs are capable of providing a stealth effect against serum proteins. American Chemical Society 2014-07-16 2014-08-13 /pmc/articles/PMC4134186/ /pubmed/25029478 http://dx.doi.org/10.1021/am5031374 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Vinluan, Rodrigo D.
Liu, Jinbin
Zhou, Chen
Yu, Mengxiao
Yang, Shengyang
Kumar, Amit
Sun, Shasha
Dean, Andrew
Sun, Xiankai
Zheng, Jie
Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption
title Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption
title_full Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption
title_fullStr Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption
title_full_unstemmed Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption
title_short Glutathione-Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption
title_sort glutathione-coated luminescent gold nanoparticles: a surface ligand for minimizing serum protein adsorption
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134186/
https://www.ncbi.nlm.nih.gov/pubmed/25029478
http://dx.doi.org/10.1021/am5031374
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