Quantifying Metabolic Heterogeneity in Head and Neck Tumors in Real Time: 2-DG Uptake Is Highest in Hypoxic Tumor Regions

PURPOSE: Intratumoral metabolic heterogeneity may increase the likelihood of treatment failure due to the presence of a subset of resistant tumor cells. Using a head and neck squamous cell carcinoma (HNSCC) xenograft model and a real-time fluorescence imaging approach, we tested the hypothesis that...

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Detalles Bibliográficos
Autores principales: Nakajima, Erica C., Laymon, Charles, Oborski, Matthew, Hou, Weizhou, Wang, Lin, Grandis, Jennifer R., Ferris, Robert L., Mountz, James M., Van Houten, Bennett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134191/
https://www.ncbi.nlm.nih.gov/pubmed/25127378
http://dx.doi.org/10.1371/journal.pone.0102452

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