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An Engineered Factor Va Prevents Bleeding Induced by Anticoagulant wt Activated Protein C

OBJECTIVE: An increased risk of bleeding is observed in patients receiving activated protein C (APC), which may be a limiting factor for the application of novel APC therapies. Since APC's therapeutic effects often require its cytoprotective activities on cells but not APC's anticoagulant...

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Detalles Bibliográficos
Autores principales:	von Drygalski, Annette, Bhat, Vikas, Gale, Andrew J., Burnier, Laurent, Cramer, Thomas J., Griffin, John H., Mosnier, Laurent O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134195/ https://www.ncbi.nlm.nih.gov/pubmed/25127130 http://dx.doi.org/10.1371/journal.pone.0104304

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