Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

Accumulating evidence links numerous abnormalities in cerebral metabolism with the progression of Alzheimer's disease (AD), beginning in its early stages. Here, we integrate transcriptomic data from AD patients with a genome-scale computational human metabolic model to characterize the altered...

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Detalles Bibliográficos
Autores principales: Stempler, Shiri, Yizhak, Keren, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134302/
https://www.ncbi.nlm.nih.gov/pubmed/25127241
http://dx.doi.org/10.1371/journal.pone.0105383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134302/
https://www.ncbi.nlm.nih.gov/pubmed/25127241
http://dx.doi.org/10.1371/journal.pone.0105383

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