Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

The ionotropic glutamate receptors (NMDAR) are composed of large complexes of multi-protein subunits creating ion channels in the cell plasma membranes that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) important for synaptic transmissions, cellular migration and survival. R...

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Detalles Bibliográficos
Autores principales: Prickett, Todd D., Zerlanko, Brad J., Hill, Victoria K., Gartner, Jared J., Qutob, Nouar, Jiang, Jiji, Simaan, May, Wunderlich, John, Gutkind, J. Silvio, Rosenberg, Steven A., Samuels, Yardena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134353/
https://www.ncbi.nlm.nih.gov/pubmed/24739903
http://dx.doi.org/10.1038/jid.2014.190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134353/
https://www.ncbi.nlm.nih.gov/pubmed/24739903
http://dx.doi.org/10.1038/jid.2014.190

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