Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma

BACKGROUND: A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2–p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:...

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Detalles Bibliográficos
Autores principales: Chen, L, Zhao, Y, Halliday, G C, Berry, P, Rousseau, R F, Middleton, S A, Nichols, G L, Del Bello, F, Piergentili, A, Newell, D R, Lunec, J, Tweddle, D A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134492/
https://www.ncbi.nlm.nih.gov/pubmed/24921920
http://dx.doi.org/10.1038/bjc.2014.325

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