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Dose of Incorporated Immunodominant Antigen in Recombinant BCG Impacts Modestly on Th1 Immune Response and Protective Efficiency against Mycobacterium tuberculosis in Mice

One approach for improving BCG efficacy is to utilize BCG as vehicle to develop recombinant BCG (rBCG) strains overexpressing Mycobacterium tuberculosis (M. tb) antigens. Also expression level of a candidate antigen should impact the final T cell responses conferred by rBCG. In this study, based on...

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Detalles Bibliográficos
Autores principales:	Ma, Hui, Wu, Kang, Liu, Fang, Yang, Hua, Kang, Han, Chen, Ning-Ning, Yuan, Qin, Zhou, Wen-Jiang, Fan, Xiao-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134796/ https://www.ncbi.nlm.nih.gov/pubmed/25152895 http://dx.doi.org/10.1155/2014/196124

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