Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes ca...

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Autor principal: Banerjee, Rona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134801/
https://www.ncbi.nlm.nih.gov/pubmed/25147492
http://dx.doi.org/10.1155/2014/325873
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author Banerjee, Rona
author_facet Banerjee, Rona
author_sort Banerjee, Rona
collection PubMed
description Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers to β-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.
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spelling pubmed-41348012014-08-21 Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation Banerjee, Rona Bioinorg Chem Appl Research Article Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers to β-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization. Hindawi Publishing Corporation 2014 2014-07-23 /pmc/articles/PMC4134801/ /pubmed/25147492 http://dx.doi.org/10.1155/2014/325873 Text en Copyright © 2014 Rona Banerjee. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Banerjee, Rona
Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation
title Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation
title_full Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation
title_fullStr Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation
title_full_unstemmed Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation
title_short Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation
title_sort inhibitory effect of curcumin-cu(ii) and curcumin-zn(ii) complexes on amyloid-beta peptide fibrillation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134801/
https://www.ncbi.nlm.nih.gov/pubmed/25147492
http://dx.doi.org/10.1155/2014/325873
work_keys_str_mv AT banerjeerona inhibitoryeffectofcurcumincuiiandcurcuminzniicomplexesonamyloidbetapeptidefibrillation

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