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The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation

BACKGROUND: Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. OBJECTIVE: The present study was designed to examine...

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Autores principales: Kim, Hyuk, Park, Kui Young, Choi, Sun Young, Koh, Hyun-Ju, Park, Sun-Young, Park, Won-Seok, Bae, Il-Hong, Kim, Beom Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135098/
https://www.ncbi.nlm.nih.gov/pubmed/25143672
http://dx.doi.org/10.5021/ad.2014.26.4.447
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author Kim, Hyuk
Park, Kui Young
Choi, Sun Young
Koh, Hyun-Ju
Park, Sun-Young
Park, Won-Seok
Bae, Il-Hong
Kim, Beom Joon
author_facet Kim, Hyuk
Park, Kui Young
Choi, Sun Young
Koh, Hyun-Ju
Park, Sun-Young
Park, Won-Seok
Bae, Il-Hong
Kim, Beom Joon
author_sort Kim, Hyuk
collection PubMed
description BACKGROUND: Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. OBJECTIVE: The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections. METHODS: A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS). RESULTS: In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone. CONCLUSION: A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation.
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spelling pubmed-41350982014-08-20 The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation Kim, Hyuk Park, Kui Young Choi, Sun Young Koh, Hyun-Ju Park, Sun-Young Park, Won-Seok Bae, Il-Hong Kim, Beom Joon Ann Dermatol Original Article BACKGROUND: Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. OBJECTIVE: The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections. METHODS: A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS). RESULTS: In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone. CONCLUSION: A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2014-08 2014-07-31 /pmc/articles/PMC4135098/ /pubmed/25143672 http://dx.doi.org/10.5021/ad.2014.26.4.447 Text en Copyright © 2014 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyuk
Park, Kui Young
Choi, Sun Young
Koh, Hyun-Ju
Park, Sun-Young
Park, Won-Seok
Bae, Il-Hong
Kim, Beom Joon
The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
title The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
title_full The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
title_fullStr The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
title_full_unstemmed The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
title_short The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation
title_sort efficacy, longevity, and safety of combined radiofrequency treatment and hyaluronic acid filler for skin rejuvenation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135098/
https://www.ncbi.nlm.nih.gov/pubmed/25143672
http://dx.doi.org/10.5021/ad.2014.26.4.447
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