Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation

In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better poten...

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Detalles Bibliográficos
Autores principales: Anthwal, Amit, Thakur, Bandana K., Rawat, M. S. M., Rawat, D. S., Tyagi, Amit K., Aggarwal, Bharat B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135142/
https://www.ncbi.nlm.nih.gov/pubmed/25157362
http://dx.doi.org/10.1155/2014/524161
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author Anthwal, Amit
Thakur, Bandana K.
Rawat, M. S. M.
Rawat, D. S.
Tyagi, Amit K.
Aggarwal, Bharat B.
author_facet Anthwal, Amit
Thakur, Bandana K.
Rawat, M. S. M.
Rawat, D. S.
Tyagi, Amit K.
Aggarwal, Bharat B.
author_sort Anthwal, Amit
collection PubMed
description In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF-α-induced NF-κB activation in comparison to curcumin, which show their potential to act as anti-inflammatory agents. Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard.
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spelling pubmed-41351422014-08-25 Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation Anthwal, Amit Thakur, Bandana K. Rawat, M. S. M. Rawat, D. S. Tyagi, Amit K. Aggarwal, Bharat B. Biomed Res Int Research Article In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF-α-induced NF-κB activation in comparison to curcumin, which show their potential to act as anti-inflammatory agents. Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard. Hindawi Publishing Corporation 2014 2014-07-24 /pmc/articles/PMC4135142/ /pubmed/25157362 http://dx.doi.org/10.1155/2014/524161 Text en Copyright © 2014 Amit Anthwal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Anthwal, Amit
Thakur, Bandana K.
Rawat, M. S. M.
Rawat, D. S.
Tyagi, Amit K.
Aggarwal, Bharat B.
Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
title Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
title_full Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
title_fullStr Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
title_full_unstemmed Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
title_short Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
title_sort synthesis, characterization and in vitro anticancer activity of c-5 curcumin analogues with potential to inhibit tnf-α-induced nf-κb activation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135142/
https://www.ncbi.nlm.nih.gov/pubmed/25157362
http://dx.doi.org/10.1155/2014/524161
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