Cargando…
NEK9-dependent proliferation of cancer cells lacking functional p53
Dysfunction of the p53 network is a major cause of cancer development, and selective elimination of p53-inactivated cancer cells therefore represents an ideal therapeutic strategy. In this study, we performed a microRNA target screen that identified NEK9 (NIMA-related kinase 9) as a crucial regulato...
Autores principales: | Kurioka, Daisuke, Takeshita, Fumitaka, Tsuta, Koji, Sakamoto, Hiromi, Watanabe, Shun-ichi, Matsumoto, Kenji, Watanabe, Masatoshi, Nakagama, Hitoshi, Ochiya, Takahiro, Yokota, Jun, Kohno, Takashi, Tsuchiya, Naoto |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135330/ https://www.ncbi.nlm.nih.gov/pubmed/25131192 http://dx.doi.org/10.1038/srep06111 |
Ejemplares similares
-
A Nucleolar Stress–Specific p53–miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network
por: Fujiwara, Yuko, et al.
Publicado: (2018) -
Circulating Exosomal microRNAs as Biomarkers of Colon Cancer
por: Ogata-Kawata, Hiroko, et al.
Publicado: (2014) -
MicroRNA‐124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells
por: Liew, Lee Chuen, et al.
Publicado: (2019) -
The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas
por: Miyazaki, Makoto, et al.
Publicado: (2018) -
Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner
por: Urata, Yuri N., et al.
Publicado: (2015)