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Shared mushroom body circuits underlie visual and olfactory memories in Drosophila
In nature, animals form memories associating reward or punishment with stimuli from different sensory modalities, such as smells and colors. It is unclear, however, how distinct sensory memories are processed in the brain. We established appetitive and aversive visual learning assays for Drosophila...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135349/ https://www.ncbi.nlm.nih.gov/pubmed/25139953 http://dx.doi.org/10.7554/eLife.02395 |
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author | Vogt, Katrin Schnaitmann, Christopher Dylla, Kristina V Knapek, Stephan Aso, Yoshinori Rubin, Gerald M Tanimoto, Hiromu |
author_facet | Vogt, Katrin Schnaitmann, Christopher Dylla, Kristina V Knapek, Stephan Aso, Yoshinori Rubin, Gerald M Tanimoto, Hiromu |
author_sort | Vogt, Katrin |
collection | PubMed |
description | In nature, animals form memories associating reward or punishment with stimuli from different sensory modalities, such as smells and colors. It is unclear, however, how distinct sensory memories are processed in the brain. We established appetitive and aversive visual learning assays for Drosophila that are comparable to the widely used olfactory learning assays. These assays share critical features, such as reinforcing stimuli (sugar reward and electric shock punishment), and allow direct comparison of the cellular requirements for visual and olfactory memories. We found that the same subsets of dopamine neurons drive formation of both sensory memories. Furthermore, distinct yet partially overlapping subsets of mushroom body intrinsic neurons are required for visual and olfactory memories. Thus, our results suggest that distinct sensory memories are processed in a common brain center. Such centralization of related brain functions is an economical design that avoids the repetition of similar circuit motifs. DOI: http://dx.doi.org/10.7554/eLife.02395.001 |
format | Online Article Text |
id | pubmed-4135349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41353492014-08-22 Shared mushroom body circuits underlie visual and olfactory memories in Drosophila Vogt, Katrin Schnaitmann, Christopher Dylla, Kristina V Knapek, Stephan Aso, Yoshinori Rubin, Gerald M Tanimoto, Hiromu eLife Neuroscience In nature, animals form memories associating reward or punishment with stimuli from different sensory modalities, such as smells and colors. It is unclear, however, how distinct sensory memories are processed in the brain. We established appetitive and aversive visual learning assays for Drosophila that are comparable to the widely used olfactory learning assays. These assays share critical features, such as reinforcing stimuli (sugar reward and electric shock punishment), and allow direct comparison of the cellular requirements for visual and olfactory memories. We found that the same subsets of dopamine neurons drive formation of both sensory memories. Furthermore, distinct yet partially overlapping subsets of mushroom body intrinsic neurons are required for visual and olfactory memories. Thus, our results suggest that distinct sensory memories are processed in a common brain center. Such centralization of related brain functions is an economical design that avoids the repetition of similar circuit motifs. DOI: http://dx.doi.org/10.7554/eLife.02395.001 eLife Sciences Publications, Ltd 2014-08-19 /pmc/articles/PMC4135349/ /pubmed/25139953 http://dx.doi.org/10.7554/eLife.02395 Text en Copyright © 2014, Vogt et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Vogt, Katrin Schnaitmann, Christopher Dylla, Kristina V Knapek, Stephan Aso, Yoshinori Rubin, Gerald M Tanimoto, Hiromu Shared mushroom body circuits underlie visual and olfactory memories in Drosophila |
title | Shared mushroom body circuits underlie visual and olfactory memories in Drosophila |
title_full | Shared mushroom body circuits underlie visual and olfactory memories in Drosophila |
title_fullStr | Shared mushroom body circuits underlie visual and olfactory memories in Drosophila |
title_full_unstemmed | Shared mushroom body circuits underlie visual and olfactory memories in Drosophila |
title_short | Shared mushroom body circuits underlie visual and olfactory memories in Drosophila |
title_sort | shared mushroom body circuits underlie visual and olfactory memories in drosophila |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135349/ https://www.ncbi.nlm.nih.gov/pubmed/25139953 http://dx.doi.org/10.7554/eLife.02395 |
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