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Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP(2) and Na(+) in a reconstituted system
GIRK channels control spike frequency in atrial pacemaker cells and inhibitory potentials in neurons. By directly responding to G proteins, PIP(2) and Na(+), GIRK is under the control of multiple signaling pathways. In this study, the mammalian GIRK2 channel has been purified and reconstituted in pl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135351/ https://www.ncbi.nlm.nih.gov/pubmed/25049222 http://dx.doi.org/10.7554/eLife.03671 |